(2S,4R)-4-hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester
- CasNo：114676-61-8
- purity：99%
Details
Quality Factory Hot Selling (2S,4R)-4-hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester 114676-61-8 with Fast Shipping
- Molecular Formula:C10H19NO3
- Molecular Weight:201.266
- Melting Point:75-78 °C
- Boiling Point:282.5±33.0 °C(Predicted)
- PKA:14.75±0.40(Predicted)
- PSA：49.77000
- Density:1.094±0.06 g/cm3(Predicted)
- LogP:1.31450
114676-61-8 Relevant articles
Regioselective directed lithiation of N-Boc 3-hydroxypyrrolidine. Synthesis of 2-substituted 4-hydroxypyrrolidines
Sunose, Mihiro,Peakman, Torren M.,Charmant, Jonathan P. H.,Gallagher, Timothy,Macdonald, Simon J. F.
, p. 1723 - 1724 (1998)
N-Boc 3-hydroxypyrrolidine 1 undergoes d...
FXR RECEPTOR MODULATOR, PREPARATION METHOD THEREFOR, AND USES THEREOF
-
Paragraph 0106; 0111, (2018/11/27)
The present disclosure disclosed a modul...
Catalysis of 3-pyrrolidinecarboxylic acid and related pyrrolidine derivatives in enantioselective anti-Mannich-type reactions: Importance of the 3-acid group on pyrrolidine for stereocontrol
Zhang, Haile,Mitsumori, Susumu,Utsumi, Naoto,Imai, Masanori,Garcia-Delgado, Noemi,Mifsud, Maria,Albertshofer, Klaus,Cheong, Paul Ha-Yeon,Houk,Tanaka, Fujie,Barbas III, Carlos F.
, p. 875 - 886 (2008/09/20)
The development of enantioselective anti...
Chiral quinolone intermediates
-
, (2008/06/13)
Chiral compounds having the formulae STR...
114676-61-8 Process route
-
-
213699-41-3
tert-butyl (2S,4R)-4-((tert-butyldimethylsilyl)oxy)-2-methylpyrrolidine-1-carboxylate
-
-
114676-61-8,2299231-07-3
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
| Conditions | Yield |
|---|---|
|
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 20 ℃;
|
99% |
|
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
for 2.5h;
Yield given;
|
|
|
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
|
-
-
114676-58-3
(2R,4R)-tert-butyl 4-((tert-butyldimethylsilyl)oxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate
-
-
114676-61-8,2299231-07-3
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 3 steps
1: 94 percent / triethylamine / CH2Cl2 / 15 h
2: lithium triethylborohydride / tetrahydrofuran / 2 h
3: tetra-n-butylammonium fluoride / tetrahydrofuran / 2.5 h
With
tetrabutyl ammonium fluoride; lithium triethylborohydride; triethylamine;
In
tetrahydrofuran; dichloromethane;
|
|
|
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 0 °C
2: sodium triethylborohydride / tetrahydrofuran / 2 h / 5 - 20 °C
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
With
tetrabutyl ammonium fluoride; sodium triethylborohydride; triethylamine;
In
tetrahydrofuran; dichloromethane;
|
114676-61-8 Upstream products
-
213699-41-3
tert-butyl (2S,4R)-4-((tert-butyldimethylsilyl)oxy)-2-methylpyrrolidine-1-carboxylate
-
109431-87-0
(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate
-
77-78-1
dimethyl sulfate
-
24424-99-5
di-tert-butyl dicarbonate
114676-61-8 Downstream products
-
477293-60-0
(2S,4S)-4-hydroxy-2-methylpyrrolidine-1-carboxylic acid tert-butyl ester
-
477293-64-4
C35H47NO3S
-
152673-32-0
(2S,4S)-4-amino-2-methylpyrrolidine-1-carboxylic acid tert-butyl ester
-
121332-92-1
7-((2S,4S)-4-Acetylamino-2-methyl-pyrrolidin-1-yl)-6-fluoro-1-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester
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