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1.What is the Methylene boldenone ?
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17β-hydroxy Exemestane is the primary active metabolite of exemestane . It is formed by metabolism of exemestane by the cytochrome P450 (CYP) isoforms CYP1A and CYP4A11. 17β-hydroxy Exemestane is an aromatase inhibitor (IC50 = 69 nM using human placental microsomes) and an androgen receptor (AR) agonist (IC50 = 39.6 nM) that is selective for AR over estrogen receptor α (ERα; IC50 = 21.2 μM). It stimulates growth of AR- and ERα-positive MCF-7 (EC50 = 2.7 μM) and T47D breast cancer cells (EC50s = 0.43 and 1,500 nM for AR- and ER-mediated growth, respectively) and inhibits proliferation of testosterone-treated aromatase-overexpressing MCF-7aro cells in a concentration-dependent manner. 17β-hydroxy Exemestane (20 mg/kg) inhibits increases in serum cholesterol and LDL levels and prevents decreases in bone mineral density in the lumbar vertebrae and femur, as well as femoral bending strength and compressive strength of the fifth lumbar vertebrae, in ovariectomized rats.
2.What is the CAS number for Methylene boldenone ?
The CAS number of Methylene boldenone is 122370-91-6.
3.What are another words for Methylene boldenone ?
Synonyms?for?Methylene boldenone 122370-91-6:17-Hydroexemestane;Hydroexemestane;
4.What is Methylene boldenone (122370-91-6) used for?
17β-Hydroxy Exemestane Sulfamate is a metabolite of Exemestane (E957000).
InChI:InChI=1/C20H26O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16,18,22H,1,4-5,7,9-10H2,2-3H3/t14-,15?,16?,18-,19+,20-/m0/s1
Relevant articles related to Methylene boldenone:
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Exemestane metabolites: Synthesis, stereochemical elucidation, biochemical activity and anti-proliferative effects in a hormone-dependent breast cancer cell line |
Varela, Carla L.,Amaral, Cristina,Tavares Da Silva, Elisiário,Lopes, Andreia,Correia-Da-Silva, Georgina,Carvalho, Rui A.,Costa, Saul C.P.,Roleira, Fernanda M.F.,Teixeira, Natércia , p. 336 - 345 (2014) |
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1,2-Dehydrogenation of steroidal 6-methylen derivatives. Synthesis of exemestane |
Marcos-Escribano, Andrés,Bermejo, Francisco A.,Bonde-Larsen, Antonio Lorente,Retuerto, Jesús Iglesias,Sierra, Ignacio Herráiz experimental part, p. 7587 - 7590 (2009/12/04) |
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Synthesis and aromatase inhibition by potential metabolites of exemestane (6-methylenandrosta-1,4-diene-3,17-dione) |
Buzzetti,Di Salle,Longo,Briatico , p. 527 - 532 (2007/10/02) |
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