Pexacerfont

  • CasNo：459856-18-9
  • purity：99%
Inquiry Add to cart

Details

Quality products?make an important contribution to long-term revenue and profitability. Factory Sells Best Quality Pexacerfont 459856-18-9 with USP

1.What is the Pexacerfont ?

(R)-sec-butylamine
13250-12-9

(R)-sec-butylamine

4-chloro-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl)[1,5-a]pyrazolo-1,3,5-triazine
459856-19-0

4-chloro-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl)[1,5-a]pyrazolo-1,3,5-triazine

[14C]-Pexacerfont
459856-18-9

[14C]-Pexacerfont

Conditions
Conditions Yield
With N-ethyl-N,N-diisopropylamine; In acetonitrile; at -5 - 25 ℃;
82%
With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 18h;
2.3 g
C<sub>9</sub>H<sub>10</sub>N<sub>2</sub>O
853569-73-0

C9 H10 N2 O

[14C]-Pexacerfont
459856-18-9

[14C]-Pexacerfont

Conditions
Conditions Yield
Multi-step reaction with 5 steps
1.1: potassium tert -butylate / tetrahydrofuran / 0.5 h / 45 °C
2.1: water; isopropyl alcohol / 4 h / 35 °C
2.2: 6 h / 5 °C
3.1: trifluoroacetic acid / acetonitrile / 7 h / 90 °C
4.1: 4-methyl-morpholine; N-ethyl-N,N-diisopropylamine; trichlorophosphate / acetonitrile / 0 - 25 °C
5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / -5 - 25 °C
With 4-methyl-morpholine; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; water; isopropyl alcohol; acetonitrile;

2.What is the CAS number for Pexacerfont ?

The CAS number of Pexacerfont is 459856-18-9.

More information of Pexacerfont 459856-18-9 are:

CAS?Number

459856-18-9

Density

1.24

Melting Point

118℃

PSA

80.46000

LogP

2.75240

Pka

2.08±0.12(Predicted)

3.What are another words for Pexacerfont ?

Synonyms?for?Pexacerfont 459856-18-9:8-(6-Methoxy-2-methyl-3-pyridinyl)-2,7-dimethyl-N-[(1R)-1-methylpropyl

4.What is the molecular formula of Pexacerfont?

The chemical formula of ?Pexacerfont is?C18H24N6O which containing 18 Carbon atoms,24 Hydrogen atoms,6 Nitrogen atoms and 1 Oxygen atoms,and the molecular weight of??Pexacerfont?is 340.428.

5.What is Pexacerfont (459856-18-9) used for?

Pexacerfont is a synthetic non-peptide corticotropin-releasing factor 1 receptor (CRF1) antagonist, designed to treat stress-related disorders and depression by blocking the binding of corticotropin-releasing factor (CRF) to its receptor, thereby potentially reducing the release of stress hormones and alleviating stress-related symptoms.
Used in Pharmaceutical Industry:
Pexacerfont is used as a therapeutic agent for the treatment of major depressive disorder, as it has shown promising results in clinical trials by modulating the stress response and alleviating depressive symptoms.
Used in Gastroenterology:
Pexacerfont is used as a treatment for irritable bowel syndrome, where it may help in managing the symptoms associated with this condition by reducing the stress response that can exacerbate gastrointestinal issues.
Further research is being conducted to explore the potential benefits of Pexacerfont in other stress-related conditions, indicating its versatility and potential impact in various areas of medicine where stress plays a significant role in the disease process.

Relevant articles related to Pexacerfont:

Article

Source

Synthesis and structure-activity relationships of 8-(pyrid-3-yl)pyrazolo[1, 5-a]-1,3,5-triazines: Potent, orally bioavailable corticotropin releasing factor receptor-1 (CRF1) antagonists

Gilligan, Paul J.,Clarke, Todd,He, Liqi,Lelas, Snjezana,Li, Yu-Wen,Heman, Karen,Fitzgerald, Lawrence,Miller, Keith,Zhang, Ge,Marshall, Anne,Krause, Carol,McElroy, John F.,Ward, Kathyrn,Zeller, Kim,Wong, Harvey,Bai, Steven,Saye, Joanne,Grossman, Scott,Zaczek, Robert,Arneric, Stephen P.,Hartig, Paul,Robertson, David,Trainor, George

experimental part, p. 3084 - 3092 (2010/02/28)

6.Buy Pexacerfont with the best price .

TIANJIN BAOLIRUITE CHEMICALS CO.,LTD is a quality supplier of Pexacerfont. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Pexacerfont 459856-18-9.

Related Products

Shopping Cart

Clear Inquiry